<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:01a163ed-ef18-72be-b486-f51baae08004,g:ebfaf80b-c73a-4245-b0dc-8c9e27a42bb6-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://precisionbiosciences.com/role/Cover" xlink:type="simple" xlink:href="dtil-20261103.xsd#Cover"/>
  <link:presentationLink xlink:role="http://precisionbiosciences.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_01a163ed-ef18-749b-815c-823bfa30f486" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_01a163ed-ef18-7aea-b5b9-1b8bddc60acf" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a163ed-ef18-749b-815c-823bfa30f486" xlink:to="loc_dei_DocumentType_01a163ed-ef18-7aea-b5b9-1b8bddc60acf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_01a163ed-ef18-7eec-b2ae-1eb2e6b848b0" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a163ed-ef18-749b-815c-823bfa30f486" xlink:to="loc_dei_DocumentPeriodEndDate_01a163ed-ef18-7eec-b2ae-1eb2e6b848b0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_01a163ed-ef18-71ed-86f2-6371649a33f7" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a163ed-ef18-749b-815c-823bfa30f486" xlink:to="loc_dei_EntityRegistrantName_01a163ed-ef18-71ed-86f2-6371649a33f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_01a163ed-ef18-796a-93ae-62acc7d14ac3" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a163ed-ef18-749b-815c-823bfa30f486" xlink:to="loc_dei_EntityIncorporationStateCountryCode_01a163ed-ef18-796a-93ae-62acc7d14ac3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_01a163ed-ef18-7b26-9371-cd9965f64a8f" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a163ed-ef18-749b-815c-823bfa30f486" xlink:to="loc_dei_EntityFileNumber_01a163ed-ef18-7b26-9371-cd9965f64a8f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_01a163ed-ef18-7e41-abb5-30255288d78c" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a163ed-ef18-749b-815c-823bfa30f486" xlink:to="loc_dei_EntityTaxIdentificationNumber_01a163ed-ef18-7e41-abb5-30255288d78c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_01a163ed-ef18-7485-85b5-d47e70057e44" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a163ed-ef18-749b-815c-823bfa30f486" xlink:to="loc_dei_EntityAddressAddressLine1_01a163ed-ef18-7485-85b5-d47e70057e44" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_01a163ed-ef18-7d6d-8f39-c68aed2a0258" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine2"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a163ed-ef18-749b-815c-823bfa30f486" xlink:to="loc_dei_EntityAddressAddressLine2_01a163ed-ef18-7d6d-8f39-c68aed2a0258" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_01a163ed-ef18-7711-989d-cb6ae73a37f0" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a163ed-ef18-749b-815c-823bfa30f486" xlink:to="loc_dei_EntityAddressCityOrTown_01a163ed-ef18-7711-989d-cb6ae73a37f0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_01a163ed-ef18-73ad-b0ba-865b5f20415e" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a163ed-ef18-749b-815c-823bfa30f486" xlink:to="loc_dei_EntityAddressStateOrProvince_01a163ed-ef18-73ad-b0ba-865b5f20415e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_01a163ed-ef18-7036-897e-db528483420a" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a163ed-ef18-749b-815c-823bfa30f486" xlink:to="loc_dei_EntityCentralIndexKey_01a163ed-ef18-7036-897e-db528483420a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_01a163ed-ef18-787d-b8fa-ca7f53c6fd21" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a163ed-ef18-749b-815c-823bfa30f486" xlink:to="loc_dei_AmendmentFlag_01a163ed-ef18-787d-b8fa-ca7f53c6fd21" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_01a163ed-ef18-7deb-8a72-5464adb9f999" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a163ed-ef18-749b-815c-823bfa30f486" xlink:to="loc_dei_EntityAddressPostalZipCode_01a163ed-ef18-7deb-8a72-5464adb9f999" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_01a163ed-ef18-7693-a0b2-d4b7f8cf0c7c" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a163ed-ef18-749b-815c-823bfa30f486" xlink:to="loc_dei_LocalPhoneNumber_01a163ed-ef18-7693-a0b2-d4b7f8cf0c7c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_01a163ed-ef18-79ed-b76a-818ade58f633" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a163ed-ef18-749b-815c-823bfa30f486" xlink:to="loc_dei_CityAreaCode_01a163ed-ef18-79ed-b76a-818ade58f633" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_01a163ed-ef18-7b84-bae7-e15ccb1bb435" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a163ed-ef18-749b-815c-823bfa30f486" xlink:to="loc_dei_WrittenCommunications_01a163ed-ef18-7b84-bae7-e15ccb1bb435" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_01a163ed-ef18-71da-a5f1-acea6eb87f9d" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a163ed-ef18-749b-815c-823bfa30f486" xlink:to="loc_dei_SolicitingMaterial_01a163ed-ef18-71da-a5f1-acea6eb87f9d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_01a163ed-ef18-7f87-bb39-1e4f99cc4997" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a163ed-ef18-749b-815c-823bfa30f486" xlink:to="loc_dei_PreCommencementTenderOffer_01a163ed-ef18-7f87-bb39-1e4f99cc4997" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_01a163ed-ef18-7a03-b1c7-ef2bb1ee4679" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a163ed-ef18-749b-815c-823bfa30f486" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_01a163ed-ef18-7a03-b1c7-ef2bb1ee4679" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_01a163ed-ef18-7d75-8179-6ef690d0b470" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a163ed-ef18-749b-815c-823bfa30f486" xlink:to="loc_dei_Security12bTitle_01a163ed-ef18-7d75-8179-6ef690d0b470" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_01a163ed-ef18-7b89-b99f-81bbabd0b052" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a163ed-ef18-749b-815c-823bfa30f486" xlink:to="loc_dei_TradingSymbol_01a163ed-ef18-7b89-b99f-81bbabd0b052" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_01a163ed-ef18-76e2-b70e-3632e71a582d" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a163ed-ef18-749b-815c-823bfa30f486" xlink:to="loc_dei_SecurityExchangeName_01a163ed-ef18-76e2-b70e-3632e71a582d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_01a163ed-ef18-7513-a7c3-bdb268f7b967" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a163ed-ef18-749b-815c-823bfa30f486" xlink:to="loc_dei_EntityEmergingGrowthCompany_01a163ed-ef18-7513-a7c3-bdb268f7b967" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
